Aptamers: Problems, Solutions and Prospects
نویسندگان
چکیده
Aptamers are short single-stranded oligonucleotides that are capable of binding various molecules with high affinity and specificity. When the technology of aptamer selection was developed almost a quarter of a century ago, a suggestion was immediately put forward that it might be a revolutionary start into solving many problems associated with diagnostics and the therapy of diseases. However, multiple attempts to use aptamers in practice, although sometimes successful, have been generally much less efficient than had been expected initially. This review is mostly devoted not to the successful use of aptamers but to the problems impeding the widespread application of aptamers in diagnostics and therapy, as well as to approaches that could considerably expand the range of aptamer application.
منابع مشابه
Aptamers against pathogenic microorganisms
An important current issue of modern molecular medicine and biotechnology is the search for new approaches to early diagnostic assays and adequate therapy of infectious diseases. One of the promising solutions to this problem might be a development of nucleic acid aptamers capable of interacting specifically with bacteria, protozoa, and viruses. Such aptamers can be used for the specific recogn...
متن کاملTherapeutic aptamers: developmental potential as anticancer drugs
Aptamers, composed of single-stranded DNA or RNA oligonucleotides that interact with target molecules through a specific three-dimensional structure, are selected from pools of combinatorial oligonucleotide libraries. With their high specificity and affinity for target proteins, ease of synthesis and modification, and low immunogenicity and toxicity, aptamers are considered to be attractive mol...
متن کامل[Frontiers in Bioscience 10, 1802-1827, May 1, 2005] 1802 APTAMERS: PROSPECTS IN THERAPEUTICS AND BIOMEDICINE
1. Abstract 2. Introduction 3. Advantages of aptamers as therapeutics 4. Aptamers as therapeutics 4.1. Aptamers against viruses and pathogens 4.1.1. Hepatitis C Virus 4.1.2. Influenza Virus 4.1.3. Whole virus inhibition (RSV & HCMV) 4.1.4. Aptamers against other pathogens 4.2. Aptamers in cancer treatment 4.2.1. Aptamers against tumor antigens 4.2.2. Aptamers against whole cells 4.3. Aptamers a...
متن کاملMultivalent Aptamers: Versatile Tools for Diagnostic and Therapeutic Applications.
Nucleic acid aptamers generated through an in vitro selection are currently extensively applied as very valuable biomolecular tools thanks to their prominent advantages. Diversity of spatial structures, ease of production through chemical synthesis and a large variety of chemical modifications make aptamers convenient building blocks for the generation of multifunctional constructs. An opportun...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2013